| Autor: |
V. Velkova, A. Bonev, N. Kortesova, E. Milusheva, K. Boev, Papasova M |
| Rok vydání: |
1981 |
| Předmět: |
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| DOI: |
10.1016/b978-0-08-026817-0.50020-2 |
| Popis: |
Publisher Summary This chapter presents a study examining mechanisms underlying the relaxation of the lower esophageal and ileocecal sphincters in the case of increased K + . Muscle strips isolated from LES and ICS of cats was used and preidentified by field stimulation. In some strips only the contractile activity was recorded while in others the MP and the contractions were followed using the sucrose gap technique. The increase of K + was performed by replacing NaCl by KCl. It was observed that the increase of K + in external solution led to relaxation of the LES and ICS strips. When K + was increased above 30 mM, the response was biphasic; initial relaxation was followed by contraction. There was a relationship between the response pattern and the K + concentration. At low K + concentrations there occurred relaxation only, and with K + at concentrations higher than 30 mM the response was biphasic. At much higher concentrations, predominance of the contractile phase was observed but the relaxation phase still persisted. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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