Isotope effect, essential diet components, and prospects of aging retardation

Autor:	M. S. Shchepinov, N. B. Pestov
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Reactive oxygen species Stable isotope ratio General Chemistry Hydrogen atom abstraction medicine.disease_cause Redox Amino acid chemistry Biochemistry Kinetic isotope effect Nucleic acid medicine Oxidative stress
Zdroj:	Russian Journal of General Chemistry. 80:1514-1522
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363210070480
Popis:	A method is proposed that has the potential to increase the stability of lipids, proteins, nucleic acids and other cellular components towards the detrimental damages caused by reactive oxygen species (ROS). The rate-limiting step of most ROS-driven oxidation reactions is hydrogen abstraction. The oxidation-susceptible sites within these (bio)molecules can thus be made less vulnerable to ROS-driven oxidation by incorporating heavy stable isotopes, such as deuterium or/and carbon-13. Ingestion of isotopically reinforced building blocks, such as amino acids, lipids, and components of nucleic acids and their subsequent incorporation into macromolecules would make the latter more stable to ROS courtesy of the isotope effect. The suggested approach may lead to enhanced resistance toward oxidative stress and, hence, to enhanced longevity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa8486c5655b2c07ea7b8709e743dbbe https://doi.org/10.1134/s1070363210070480 Zobrazit plný text záznamu Plný text ve formátu PDF