Anticomplement cycloartane triterpene glycosides from Beesia calthaefolia (Maxim.)
Autor: | Ping Liu, Li Hua Mu, Jin Yuan Zhao |
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Rok vydání: | 2016 |
Předmět: |
chemistry.chemical_classification
Chemical compound 010405 organic chemistry Chemistry Stereochemistry Rosmarinic acid Glycoside Plant Science 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry Classical complement pathway chemistry.chemical_compound Triterpene Agronomy and Crop Science Two-dimensional nuclear magnetic resonance spectroscopy IC50 PubChem Biotechnology |
Zdroj: | Phytochemistry Letters. 16:47-51 |
ISSN: | 1874-3900 |
DOI: | 10.1016/j.phytol.2016.02.015 |
Popis: | Investigation of the n-BuOH extract of the whole plant of Beesia calthaefolia led to the isolation of three new cycloartane triterpenoids (1–3) and two known compounds (4, 5). Their structures were elucidated by 1D and 2D NMR, HRESIMS and optical rotation spectral data. All of the isolates were investigated for their inhibitory effects on the classical pathway of the complement system. Among them, compound 3 showed stronger inhibitory activity (IC50 148.0 μM) than the positive control (rosmarinic acid, IC50 181.8 μM), while other compounds (1, 2, 4 and 5) showed moderate activity. The chemical compound studied in this article was rosmarinic acid (PubChem CID: 5281792). |
Databáze: | OpenAIRE |
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