1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction

Autor:	Inna V. Aksenova, K. A. Frolov, Sergey G. Krivokolysko, Victor V. Dotsenko, A. N. Khrustaleva, N. A. Aksenov
Rok vydání:	2021
Předmět:	Ethanol Primary (chemistry) 010405 organic chemistry In silico Biological activity General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Pyridine Mannich reaction
Zdroj:	Russian Journal of General Chemistry. 91:44-56
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363221010047
Popis:	1,6-Diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles under the action of primary aliphatic amines and an excess of 37% formalin in ethanol were converted into 2,3,8,9-tetrahydro-6,10-methano[1,2,4]triazolo[1,5-a][1,5]diazocine-6,10(7H)-dicarbonitrile derivatives. At the same time, the Mannich reaction in the case of 1,6-diamino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles proceeds ambiguously, and, depending on the conditions, gives either N-ethoxymethylation products or 1,2,4-triazolo[1,5-a]pyridine derivatives. In silico predictive analysis of the biological activity of new compounds was carried out.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa771009221469e05d0b657e21ba1c16 https://doi.org/10.1134/s1070363221010047 Zobrazit plný text záznamu Plný text ve formátu PDF