Study of direct macrocycle formation via the cyclisation of propargyl 2-azidobenzoate

Autor:	Pavel Hradil, Martin Grepl, Ludmila Hradilová, Barbora Dvořáková
Rok vydání:	2013
Předmět:	Reaction conditions Chemistry Organic Chemistry Drug Discovery Propargyl Click chemistry Organic chemistry Biochemistry Combinatorial chemistry Catalysis
Zdroj:	Tetrahedron Letters. 54:1218-1221
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2012.12.076
Popis:	Macrocycles were synthesised via the cyclisation of propargyl 2-azidobenzoate using ‘click’ chemistry. An LC/MS-based method for the separation of macrocycles is described. In the present work, the influence of various catalysts and reaction conditions on the course of the reaction is evaluated. The reaction is very sensitive to the conditions, and it is demonstrated that it is possible to modify the ratio of macrocycles by varying the reaction conditions. The cyclisation of propargyl 2-azidobenzoate represents an economical method for the preparation of the studied macrocycles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa72377983f1ce54ce98913867d21e30 https://doi.org/10.1016/j.tetlet.2012.12.076 Zobrazit plný text záznamu Full Text from ScienceDirect