Specific Activation of the Insulin Receptor by the Transmembrane Domain Peptides

Autor:	Mitsukuni Shibue, Takashi Fujiura, Jongsoon Lee, Hideaki Maeda, Steven E. Shoelson, Masaya Miyazaki
Rok vydání:	2001
Předmět:	Receptor Activation Process biology Chemistry Insulin medicine.medical_treatment Cell biology stomatognathic diseases Insulin receptor Transmembrane domain Insulin receptor substrate medicine biology.protein Enzyme-linked receptor Binding site human activities Tyrosine kinase
Zdroj:	Peptides: The Wave of the Future ISBN: 9789401039055
DOI:	10.1007/978-94-010-0464-0_427
Popis:	The binding of insulin to the extracellular domain of the insulin receptor (IR) triggers activation of tyrosine kinase and transmits the signal to the downstream signaling cascade [1]. However, it is still unknown how insulin binding to the extracellular binding site causes receptor activation. Several studies using IR mutants have investigated the function of the transmembrane domain (TMD) in the receptor activation process, and it was suggested that the TMD might have some role in the receptor activation [2,3]. We report here a different approach using a synthetic peptide corresponding to the TMD of IR (IR-TM), to investigate the role of TMD in receptor activation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa6f62b437431aa4197bc5251b441d01 https://doi.org/10.1007/978-94-010-0464-0_427 Zobrazit plný text záznamu