Consecutive catalytic electrophilic fluorination/amination of β-keto esters: toward α-fluoro-α-amino acids?

Autor:	Kyrill Stanek, Antonio Togni, Dominique P. Huber
Rok vydání:	2006
Předmět:	chemistry.chemical_classification Tetrafluoroborate Organic Chemistry Electrophilic fluorination Catalysis Amino acid Inorganic Chemistry chemistry.chemical_compound chemistry Organic chemistry Physical and Theoretical Chemistry Selectfluor Amination Octane
Zdroj:	Tetrahedron: Asymmetry. 17:658-664
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2006.01.035
Popis:	Monofluorination of β-keto esters with Selectfluor ® (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2,2,2]octane bis(tetrafluoroborate)) using CpTiCl 3 as a catalyst, followed by amination with diazodicarboxylates using a Cu/Ph-Box catalyst leads to α-fluoro-α-hydrazino-β-keto esters in good yields and good selectivities (ee up to 94%).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa67faba63508d725b6b880d6b7c74f8 https://doi.org/10.1016/j.tetasy.2006.01.035 Zobrazit plný text záznamu Full Text from ScienceDirect