The Effect of L-Carnitine and Proinflammatory Cytokines in the Development of Nonalcoholic Steatohepatitis
| Autor: | Svetlana Vladimirovna Glushchenko, Tetyana Dmitrivna Zvyagintseva |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Nonalcoholic steatohepatitis medicine.medical_specialty biology business.industry Inflammation General Medicine Proinflammatory cytokine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Blood serum Internal medicine Immunology medicine biology.protein 030211 gastroenterology & hepatology Tumor necrosis factor alpha Carnitine medicine.symptom Inverse correlation Interleukin 6 business medicine.drug |
| Zdroj: | Bangladesh Journal of Medical Science. 15:62-65 |
| ISSN: | 2076-0299 2223-4721 |
| DOI: | 10.3329/bjms.v15i1.20660 |
| Popis: | Objective : research is to study the role of L-carnitine, tumor necrosis factor α (TNF-α), and interleucine-6 (IL-6) in the development of NASH. Materials and Methods : examined 65 patients with NASH. Blood serum L-carnitine, TNF-α and IL-6 level was estimated using the enzyme-linked immunoassay method. Results : patients with NASH had a decreased blood serum level of L-carnitine. L-carnitine level was found to be in strong inverse correlation dependence on cellular damage markers, L-carnitine levels affect the performance TNF-α and IL-6. Conclusion : L-carnitine contributes to lipotoxic stress development and development of systemic liver inflammation. Bangladesh Journal of Medical Science Vol.15(1) 2016 p.62-65 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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