Mass-spectrometry analysis of disflurane, propofol, and fentanyl in plasma and cerebrospinal fluid
| Autor: | A. Yu. Elizarov |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Chromatography
Chemistry 010401 analytical chemistry Biophysics Analytical chemistry Mass spectrometry 01 natural sciences 0104 chemical sciences Fentanyl 03 medical and health sciences 0302 clinical medicine Membrane Cerebrospinal fluid Anesthetic Blood plasma medicine 030216 legal & forensic medicine Pervaporation Propofol medicine.drug |
| Zdroj: | Biophysics. 61:494-497 |
| ISSN: | 1555-6654 0006-3509 |
| DOI: | 10.1134/s0006350916030027 |
| Popis: | Concentrations of anesthetic agents were measured in blood plasma and cerebrospinal fluid using mass spectrometry with a membrane interface. Sampling of biological fluids was performed during balanced inhalational (disflurane and fentanyl) anesthesia and total intravenous (propofol and fentanyl) anesthesia. A rapid test method for the concentration measurement of organic molecules in biological fluids is described. This method does not require long-term sample processing before injecting the sample into the mass spectrometer interface. The pervaporation properties (uptake, diffusion, and evaporation) of anesthetic agents from biological fluids in a silicone membrane were used in the mass spectrometry interface. We report on the possibility of using a mass spectrometer with a membrane interface for the measurement of the absolute concentration of anesthetic agents in blood plasma for study of the properties of the blood–brain barrier. |
| Databáze: | OpenAIRE |
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