Construction of C-glycosides of heterocycles containing the pyrimidin-2-amine or the 1H-pyrazolo[3,4-b]pyridine moiety and their biological evaluation for anticancer activities

Autor:	Yan-Ping Jiang, Qiao Wang, Zunting Zhang, Yu-Tao Zhang, Wu-Wu Li, Mei Wang, Ming-Xiang Ji, Min-Yan Zheng, Ying Guo, Ji-Chang Han
Rok vydání:	2019
Předmět:	Antitumor activity C glycosides Chemistry Amine gas treating General Chemistry Condensation reaction Medicinal chemistry Heterocyclic derivatives Pyridine moiety Biological evaluation
Zdroj:	Journal of Chemical Research. 43:152-157
ISSN:	2047-6507 1747-5198
DOI:	10.1177/1747519819856942
Popis:	A series of novel C-glycosides of heterocyclic derivatives containing a pyrimidin-2-amine or a 1 H-pyrazolo[3,4- b]pyridine moiety were synthesized using condensation reactions of the substituted puerarin with guanidine or 3-amino-5-hydroxypyrazole in methyl alcohol. Their chemical structures were characterized by Fourier-transform infrared spectroscopy, nuclear magnetic resonance, and high-resolution mass spectrometry. In addition, their biological activity has been demonstrated by in vitro evaluation against the human leukemia cells K562 and human prostate cancer cells PC-3 by MTT-based assays, using the commercially available standard drug of cis-platin as a positive control. The results also demonstrated that most of the compounds showed considerable cytotoxicity to these two cell lines of K562 and PC-3, and indicated that novel C-glycosides of heterocyclic derivatives may be potential leads for further biological screenings and may generate drug-like molecules.
Databáze:	OpenAIRE
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