Retracted:Safety and efficacy of tramadol in the treatment of idiopathic detrusor overactivity: a double-blind, placebo-controlled, randomized study

Autor:	Mohammad Reza Safarinejad, S Y Hosseini
Rok vydání:	2006
Předmět:	Pharmacology Randomization business.industry Analgesic Urinary incontinence Placebo medicine.disease law.invention Randomized controlled trial Overactive bladder law Anesthesia medicine Pharmacology (medical) Tramadol medicine.symptom Adverse effect business medicine.drug
Zdroj:	British Journal of Clinical Pharmacology. 61:456-463
ISSN:	0306-5251
DOI:	10.1111/j.1365-2125.2006.02597.x
Popis:	Aim To evaluate the efficacy and safety of tramadol in patients with idiopathic detrusor overactivity (IDO). Methods A total of 76 patients 18 years or older with IDO were randomly assigned to receive 100 mg tramadol sustained release (group 1, n = 38) or placebo (group 2, n = 38) every 12 h for 12 weeks. Clinical evaluation was performed at baseline and every 2 weeks during treatment. All patients underwent urodynamics and ice water test at baseline and 12-week treatment. Main outcome measures were number of voids per 24 h, urine volume per void and episodes of urge incontinence per 24 h on a frequency volume chart and detailed recording of adverse effect. Results After 12 weeks of treatment mean number of voids per 24 h ± SD decreased from 9.3 ± 3.2 to 5.1 ± 2.1 (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa58d6f31960211099e17a0bf72eaee1 https://doi.org/10.1111/j.1365-2125.2006.02597.x Zobrazit plný text záznamu Plný text