The process of continuous production and isolation of coproporphyrin
Autor: | Kotal P, Jan Sperl, Milan Jirsa, V. Kordač |
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Rok vydání: | 1988 |
Předmět: | |
Zdroj: | Biotechnology Letters. 10:273-276 |
ISSN: | 1573-6776 0141-5492 |
DOI: | 10.1007/bf01024418 |
Popis: | The production of coproporphyrin from glucose and urea has been achieved by semi-aerobic culture ofSaccharomyces cerevisiae. The cells were entrapped in alginate gel and packed into a column reactor for continuous long-term process. The porphyrins were isolated and simultaneously concentrated from the effluent by liquid-solid phase extraction, purified by liquid chromatography and finally crystallized. Using the process described the final product of high purity was obtained. |
Databáze: | OpenAIRE |
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