Investigation of the relationship between CE cyst characteristics and genetic diversity of Echinococcus granulosus sensu lato in humans from Turkey
| Autor: | Yakut Akyön, Serra Orsten, Çetin İmamoğlu, Ergun Karaagaoglu, Devrim Akinci, Turkmen Ciftci, Adriano Casulli, Aycan Uysal, Okan Akhan, Gokhan Yuce, Aynur Azizova |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Genetic diversity 030231 tropical medicine Zoology 030108 mycology & parasitology Biology biology.organism_classification medicine.disease law.invention 03 medical and health sciences 0302 clinical medicine Infectious Diseases Sensu law parasitic diseases Genotype Genetic variation medicine Animal Science and Zoology Parasitology Cyst Genetic variability Echinococcus granulosus Polymerase chain reaction |
| Zdroj: | Parasitology. 147:1712-1717 |
| ISSN: | 1469-8161 0031-1820 |
| DOI: | 10.1017/s0031182020001535 |
| Popis: | Cystic echinococcosis (CE) is one of the most common zoonotic diseases worldwide, particularly in rural areas. This study aimed at the identification of the genotype/species belonging to Echinococcus granulosus sensu lato (s.l.) specimens in retrieved percutaneously from the human host and to investigate their relationship with cyst characteristics. The genetic identification of cyst material was performed by mt-CO1 gene polymerase chain reaction, and confirmed via sequencing. A total of 110 CE cysts were identified as E. granulosus s.l. In detail, 104 belonged to E. granulosus sensu stricto (G1 and G3) and six isolates were in the E. canadensis cluster (G6/7). All clusters were tested for the relationship between demographics, cyst features and genetic diversity. The relationship between genetic variation and certain clinical characteristics such as cyst volume and location were statistically significant for G6/7 cluster. Further studies are required with a larger sample set to investigate the relationship between the genetic variability of E. granulosus s.l. and cyst features. |
| Databáze: | OpenAIRE |
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