Copper-Catalyzed N-Arylation of Sulfoximines with Arylboronic Acids under Mild Conditions
| Autor: | Surabhi Gupta, Shahulhameed Sabiah, Jeyakumar Kandasamy, Nalluchamy Muniyappan, Siddharth Baranwal |
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| Rok vydání: | 2019 |
| Předmět: |
Steric effects
Reaction conditions chemistry.chemical_classification 010405 organic chemistry Organic Chemistry Iodide Methionine Sulfoximine chemistry.chemical_element 010402 general chemistry 01 natural sciences Combinatorial chemistry Copper Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Copper catalyzed Boronic acid |
| Zdroj: | Synthesis. 51:2171-2182 |
| ISSN: | 1437-210X 0039-7881 |
| DOI: | 10.1055/s-0037-1612216 |
| Popis: | N-Arylation of sulfoximines with different arylboronic acids, including sterically hindered boronic acids, is achieved using copper(I) iodide and 4-DMAP at room temperature. Moreover, N-arylation of biologically relevant l-methionine sulfoximine is demonstrated for the first time. All these reactions provided the desired products in excellent yields within a short span of time. The optimized reaction conditions are well suited to the task of N-vinylation of sulfoximine with trans-2-phenylvinylboronic acid. |
| Databáze: | OpenAIRE |
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