A comparison of the efficacy and safety of the combination mometasone furoate 0.1%/salicylic acid 5% ointment with each of its components in psoriasis

Autor:	Leonard J. Swinyer, Cynthia A. Cuffie, H. I. Katz, H. L. Roth, Roland S. Medansky, Nicholas J. Lowe, N. I. Brody, Joel S. Shavin, C. J. Garcia, Daniel J. Tanner
Rok vydání:	1998
Předmět:	medicine.medical_specialty Erythema business.industry medicine.drug_class Mometasone furoate Dermatology medicine.disease chemistry.chemical_compound chemistry Cosyntropin Psoriasis Toxicity Medicine Corticosteroid medicine.symptom business Adverse effect Salicylic acid medicine.drug
Zdroj:	Journal of Dermatological Treatment. 9:151-156
ISSN:	1471-1753 0954-6634
DOI:	10.3109/09546639809160546
Popis:	A controlled, double-blind, parallel-group, multicenter comparison study enrolled 341 patients with moderate to severe psoriasis. The efficacy and safety of twice-daily application for 3 weeks of the combination ointment mometasone furoate 0.1%/salicylic acid 5% was compared with that of its individual components, mometasone furoate 0.1% ointment and salicylic acid 5% ointment. The severity of erythema, induration, and scaling of preselected target lesions was scored at baseline and days 4, 8, 15, and 22, in addition to the investigator's global evaluation of clinical response of all treated lesions (target and nontarget) at each follow-up visit. Adverse events were monitored and scored at all centers. Changes in routine laboratory values, hypothalamic-pituitary-adrenal (HPA) axis suppression by cosyntropin testing, and salicylic acid blood levels were monitored at two centers. The combination ointment was shown to be statistically significantly more effective than each of its components (P < 0.01). Treat...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa526969d36e7dcfeffd69fc78f32823 https://doi.org/10.3109/09546639809160546 Zobrazit plný text záznamu