Autor:	Rita V. Chertkova, Kirpichnikov Mp, Irina A. Kostanyan, M. V. Astapova, E. A. Surina, Dmitry A. Dolgikh
Rok vydání:	2003
Předmět:	chemistry.chemical_classification Circular dichroism Organic Chemistry Peptide Biological activity medicine.disease Biochemistry Leukemia chemistry Cell culture medicine Bioorganic chemistry Protein secondary structure Promyelocyte
Zdroj:	Russian Journal of Bioorganic Chemistry. 29:26-32
ISSN:	1068-1620
Popis:	The ABB-df artificial protein was prepared by inserting the TGENHR biologically active peptide corresponding to the 41–46 sequence of the differentiation factor for the HL-60 cell line of the human promyelocyte leukemia into the N-terminus of the polypeptide chain of albebetin, an artificial protein with the preset structure. The ABB-df protein was found to induce the differentiation of HL-60 cells and to inhibit their proliferation; its efficiency was almost the same as that of the starting peptide. According to CD spectroscopy, the inclusion of the peptide fragment into albebetin exerts virtually no effect on the regular secondary structure of albebetin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa4e4412b81ea852bccc414bcc6c215f https://doi.org/10.1023/a:1022274301659 Zobrazit plný text záznamu Full text from SpringerLink