HLA-DQ alleles in patients with celiac disease in Turkey
| Autor: | S. Sökücü, Tülay Erkan, Beyhan Tüysüz, Tufan Kutlu, Nihan Erginel-Unaltuna, A. Dursun, Ö. Süoğlu, Naci Cine, Güngör T.Tümay |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
musculoskeletal diseases
Genetics medicine.medical_specialty endocrine system diseases business.industry Immunology Haplotype nutritional and metabolic diseases General Medicine Disease Control subjects Biochemistry Gastroenterology Internal medicine HLA-DQ Immunology and Allergy Medicine In patient Primer (molecular biology) Allele skin and connective tissue diseases business Genotyping |
| Zdroj: | Tissue Antigens. 57:540-542 |
| ISSN: | 0001-2815 |
| DOI: | 10.1034/j.1399-0039.2001.057006540.x |
| Popis: | The prevalence of the HLA-DQA1 and DQB1 alleles in 55 Turkish children with celiac disease and 50 control subjects was investigated by using an allele-specific DNA-based polymerase chain reaction-sequence-specific primer (PCR-SSP) method. The frequency of the DQA1*0501 and DQB1*02 alleles was higher in celiac patients than in controls. The DQA1B1 (*0501; *02) haplotype was present in 46 (83.6%) patients and only in 12 (24%) controls. The remaining 9 celiac patients which were negative for DQA1B1 (*0501;*02) carried the DQA1B1 (*03;*0302) haplotype. We found an excess homozygosity of the DQB1*02 allele and the DQA1B1 (*0501;*02) haplotype in the patients. No statistically significant correlation was found between the homozygosity of this haplotype or the DQB1*02 allele and an earlier onset of the disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|