Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors

Autor:	Jaemoon Lee, Audrey Molina, Bob Reamer, Ioannis N. Houpis, Paul J. Reider, Ralph P. Volante, Ilias Dorziotis
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Olefin fiber Aryl Organic Chemistry Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Nucleophile Yield (chemistry) Reagent Drug Discovery Organic chemistry Alkyl Conjugate
Zdroj:	Tetrahedron. 54:1185-1195
ISSN:	0040-4020
Popis:	Alkyl, aryl, and vinyl Grignard reagents were added to olefin II under Ni(acac) 2 or Cl 2 Ni(PPh 3 ) 2 catalysis to give products with the general formula I in 74–95% yield. Organozincates gave similar results with Ni(acac) 2 as the catalyst.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa4c3da73c7b0f4cc4964b48c00a6c1a https://doi.org/10.1016/s0040-4020(97)10217-4 Zobrazit plný text záznamu Full Text from ScienceDirect