Bromocyclization of Unsaturated Oximes. Synthesis of Five-Membered Cyclic Nitrones (Pyrroline N-Oxides)
| Autor: | Volker Jäger, Stefan Schmidt, M. Gulla, Leo Redcliffe, Lars Bierer |
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| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Zeitschrift für Naturforschung B. 61:471-485 |
| ISSN: | 1865-7117 0932-0776 |
| DOI: | 10.1515/znb-2006-0414 |
| Popis: | The cyclization of a ribose-derived pentenose oxime with various halogen electrophiles showed bromine to be the most effective reagent, leading to 80% of L-lyxo/D-ribo-pyrroline N-oxides in an 84:16 diastereomeric ratio. In order to explore the scope of this facile process, several other γ,δ - unsaturated oximes were submitted to this reaction. Depending on the substitution pattern, 23 - 87%, yields of pyrroline N-oxides of were registered. With α-allyl-β -ketoester oximes the alkoxycarbonyl group proved a similar (ethoxy) or even better (t-butoxy) trapping nucleophile, leading preferentially to the corresponding bromolactone oxime. - With 2,2-dimethyl-3-butene aldoxime, the corresponding 3-bromopyrroline N-oxide was formed, due to a formal, unusual N-endo cyclization to the chain terminus. This was exploited for a new access to six-membered nitrones from a γ,δ -pentene aldoxime, with addition of Br/OH to the C=C of the 4-pentenal first, and oximation/cyclization following then |
| Databáze: | OpenAIRE |
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