Dynamics of Changes in the Fatty Acid Composition of the Auditory Cortex of the Brain in Rats after Single Audiogenic Convulsions
| Autor: | A. V. Aripovskii, T. A. Savina, T. G. Shchipakina, Oleg V. Godukhin, T. P. Kulagina |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification medicine.medical_specialty General Neuroscience Fatty acid Brain damage Auditory cortex Inherited Predisposition 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Convulsive Seizures chemistry Biochemistry Internal medicine medicine Fatty acid composition medicine.symptom 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience and Behavioral Physiology. 47:168-172 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-016-0381-z |
| Popis: | A small but significant increase in the quantity of lipid peroxidation-resistant saturated and monounsaturated fatty acids was found in the auditory cortex of Krushinskii–Molodkina (KM) rats, which have an inherited predisposition to audiogenic convulsions, as compared with Wistar rats. Assessment of the fatty acid composition of the auditory cortex in KM rats at 1 h and 1, 3, and 14 days after single audiogenic convulsions revealed changes at three days, evidencing significant depletion of the fatty acid pool at this time. At 14 days, the auditory cortex of KM rats showed recovery of most fatty acids. These results may be of value in developing new approaches to eliminating brain damage after convulsive seizures. |
| Databáze: | OpenAIRE |
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