6-[(Dimethylamino)methylene]amino-1,3-dimethyluracil: A versatile aza-diene substrate for cycloaddition and michael-type reactions

Autor:	Zhu Naijue, Eileen B. Walsh, Guo Fang, Heinrich Wamhoff
Rok vydání:	1988
Předmět:	chemistry.chemical_compound Diene chemistry Bicyclic molecule Stereochemistry Organic Chemistry Drug Discovery Michael reaction Substrate (chemistry) Methylene Biochemistry Medicinal chemistry Cycloaddition
Zdroj:	Tetrahedron Letters. 29:4401-4404
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)80505-5
Popis:	6-[(Dimethylamino)methylene]amino-1,3-dimethyluracil 1 undergoes formal [4+2] cycloaddition reactions with electron deficient olefins to give pyrido[2,3-d]pyrimidines. With DMAD or azodicarboxylates Michael addition occurs leading to pyrrolo[3,4-c]pyridines (X-ray analysis) and theophylline derivatives.
Databáze:	OpenAIRE
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