| Popis: |
Background : Medicines are the most common medical interventions to relieve sufferings but as said rightly “drugs are double edged weapons’’ with a potential to cause benefit, as well as harm. Methods : A prospective hospital -based study over a period of six months (January 2015 -june 2015) was carried out by the Department of Pharmacology under PvPIinKamineni Institute Of Medical Sciences. The ADRs of in-patient and outpatient were r ecorded. The data were subjected to descriptive analysis. The study plan included analysis and assessment of the clinical pattern, spectrum of ADRs reported based on causality, severity, preventability factors. Results : A total of 100 patients were included in study. Out of which 58%(34.81±6.43) were females and 42% ( 35.47± 7.23)males. The most common drug group causing ADRs was antimicrobials (51%), followed by NSAID’s(20%) and anti -epileptics (10%). The dermatological reactions (43%) were more, followed by gastrointestinal system (31%) and CNS (18%). Majority of ADR’s were reported from O BG department (27%) followed by orthopaedics (24%).95% of ADRs wer e non-serious, 5% were serious but recovered. As per WHO assessment method 77% ADRs were probable and 23% possible. Conclusion : The clinical spectrum of ADRs ranged from the more common mild reactions such as skin rashes, itching, nausea, and vomiting to moderately sever e reactions prolonging the hospital stay. The predominant causative drugs were antimicrobials, non-steroidal anti-inflammatory drugs. The majority of ADRs were probable/likely i n causality assessment, mild in severity and probably preventable. ADRs contribute to increased morbidity and mortality in patients; thereby pose a huge burden on the society. |
