Biodegradable cellulose-based superabsorbent as potent hemostatic agent
| Autor: | Ahmad Mahmoodzadeh, Abbas Ebrahimi Kalan, Mahdi Edalati, Roya Salehi, Jafarsadegh Moghaddas, Seyedhosein Jarolmasjed |
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| Rok vydání: | 2021 |
| Předmět: |
Hemostatic Agent
medicine.diagnostic_test Chemistry General Chemical Engineering Complete blood count Biomaterial 02 engineering and technology General Chemistry Absorption (skin) 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Industrial and Manufacturing Engineering 0104 chemical sciences Clotting time Bleeding time In vivo medicine Environmental Chemistry 0210 nano-technology Biomedical engineering Partial thromboplastin time |
| Zdroj: | Chemical Engineering Journal. 418:129252 |
| ISSN: | 1385-8947 |
| DOI: | 10.1016/j.cej.2021.129252 |
| Popis: | Engineering of effective and biocompatible hemostatic materials to control massive bleeding is one of the interesting research fields. Herein, cellulose-based polymer modified by silica aerogel and calcium chloride was used for suitable control of bleeding. Novel developed superabsorbent (NDS) was synthesized by chemical and physical cross-linking methods. NDS not only quickly absorbs a high amount of blood component (60 g/g), but it can also adhere strongly (~90 KPa) to damaged tissue. The contributions of the freeze-drying method and presence of silica aerogel as structural modifiers led to the creation of a superabsorbent with a porosity percentage of 70% which creates a significant ability to absorb blood cells. NDS negative surface charge and presence of silica nanoparticles and calcium ions accelerate activation of the coagulation cascade process. Superior hemostatic ability of NDS compared to commercial hemostatic powder (Gelita-Cel® and Traumastem®) was proved by complementary tests such as blood absorption content, RBC attachment, blood clotting index (BCI), platelet adhesion, clotting time test and partial thromboplastin time (PTT). In vivo study results demonstrate that the NDS could successfully decrease bleeding time and blood loss amount in Wistar rat’s cut-out femoral artery, 2.25 and 4.3 fold better than Gelita-Cel® and 2.13 and 4.4 fold better than Traumastem®. NDS biodegradability was proved by its implantation inside the Wistar rat's body during 14 days. Biochemical, hematological, and pathological tests did not show inflammation and toxic effects in the liver and renal tissues, skin tissues, and alteration in complete blood count parameters (CBC) in NDS treated Wistar rats. In conclusion, the cellulose-based NDS hemostatic biomaterial is suggested for future clinical trial studies due to its powerful ability in bleeding control. |
| Databáze: | OpenAIRE |
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