The Yersinia Type III Secretion System as a Tool for Studying Cytosolic Innate Immune Surveillance

Autor:	Katherine A. Schubert, Feng Shao, Yue Xu, Victoria Auerbuch
Rok vydání:	2020
Předmět:	Innate immune system biology Host (biology) Pyroptosis Inflammasome biochemical phenomena metabolism and nutrition Yersinia biology.organism_classification Microbiology Pyrin domain Type three secretion system Cell biology medicine bacteria Receptor medicine.drug
Zdroj:	Annual Review of Microbiology. 74:221-245
ISSN:	1545-3251 0066-4227
DOI:	10.1146/annurev-micro-020518-120221
Popis:	Microbial pathogens have evolved complex mechanisms to interface with host cells in order to evade host defenses and replicate. However, mammalian innate immune receptors detect the presence of molecules unique to the microbial world or sense the activity of virulence factors, activating antimicrobial and inflammatory pathways. We focus on how studies of the major virulence factor of one group of microbial pathogens, the type III secretion system (T3SS) of human pathogenic Yersinia, have shed light on these important innate immune responses. Yersinia are largely extracellular pathogens, yet they insert T3SS cargo into target host cells that modulate the activity of cytosolic innate immune receptors. This review covers both the host pathways that detect the Yersinia T3SS and the effector proteins used by Yersinia to manipulate innate immune signaling.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa26846e574057e7fcac7754df80345c https://doi.org/10.1146/annurev-micro-020518-120221 Zobrazit plný text záznamu