THE GABA-ERGIC SYSTEM DOES NOT CONTROL THE NOCICEPTIVE RESPONSES OF PRIMARY SENSORY NEURON

Autor:	Boris V. Krylov, S. A. Podzorova, V. A. Penniyaynen, V. B. Plakhova, S. G. Terekhin
Rok vydání:	2019
Předmět:	medicine.anatomical_structure Nociception nervous system Neurite Nervous tissue Primary sensory neuron medicine Sensory system Neuron Gating Biology Neuroscience Peripheral
Zdroj:	Medical academic journal. 19:44-45
ISSN:	1608-4101
DOI:	10.17816/maj191s144-45
Popis:	The aim of the study was to elucidate the molecular mechanisms of the interconnection of the GABA-ergic and nociceptive systems at the level of the peripheral division of the CNS. The data obtained indicate that GABA does not affect the activation gating device of the NaV1.8 channel of the primary sensory neuron responsible for coding pain signals.This agent in a wide range of concentrations also does not affect the growth of neurites of sensory neurons of embryonic nervous tissue. These results confirm our assumption, expressed earlier that the asynaptic membrane of the primary nociceptive neuron is not under the control of the GABA-ergic system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fa1b9b6fbf68d4204167fcbc730b6fbe https://doi.org/10.17816/maj191s144-45 Zobrazit plný text záznamu