Abstracts
| Autor: | Caitlin M Brown, Brad Reisfeld, Arthur N. Mayeno |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
chemistry.chemical_classification
biology Cytochrome P450 respiratory system Chemical classification Isozyme chemistry.chemical_compound Enzyme Biochemistry Biotransformation chemistry biology.protein Structure–activity relationship Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Pharmacophore Xenobiotic |
| Zdroj: | Drug Metabolism Reviews. 40:1-288 |
| ISSN: | 1097-9883 0360-2532 |
| DOI: | 10.1080/03602530802309742 |
| Popis: | Cytochromes P450 (CYPs) are a superfamily of enzymes that metabolize the majority of xenobiotics in humans. This review presents a structure-based outline of CYP-catalyzed biotransformations of selected substrates, representing diverse structural classes of chemicals, ranging from drugs to toxicants. Data are presented in a tabular format for easy reference, with visual representations of all substrates and sites-of-attack. The major metabolites, isozymes responsible, chemical classification, and other information related to the biotransformation are provided. Pharmacophores proposed for the major CYP isozymes are discussed. This visual combination of substrates and biotransformation sites can serve as a useful reference for researchers. |
| Databáze: | OpenAIRE |
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