Effects of Electronic Nicotine Delivery Systems and Cigarettes on Systemic Circulation and Blood-Brain Barrier
| Autor: | Nathan A. Heldt, Nancy L. Reichenbach, Hannah McGary, Yuri Persidsky |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Harm reduction business.industry Vascular disease Disease Blood–brain barrier medicine.disease Bioinformatics Tobacco smoke Pathology and Forensic Medicine Nicotine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Nicotinic agonist medicine Cognitive decline business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The American Journal of Pathology. 191:243-255 |
| ISSN: | 0002-9440 |
| DOI: | 10.1016/j.ajpath.2020.11.007 |
| Popis: | Electronic nicotine delivery systems (often known as e-cigarettes) are a novel tobacco product with growing popularity, particularly among younger demographics. The implications for public health are twofold, as these products may represent a novel source of tobacco-associated disease but may also provide a harm reduction strategy for current tobacco users. There is increasing recognition that e-cigarettes impact vascular function across multiple organ systems. Herein, we provide a comparison of evidence regarding the role of e-cigarettes versus combustible tobacco in vascular disease and implications for blood-brain barrier dysfunction and cognitive decline. Multiple non-nicotinic components of tobacco smoke have been identified in e-cigarette aerosol, and their involvement in vascular disease is discussed. In addition, nicotine and nicotinic signaling may modulate peripheral immune and endothelial cell populations in a highly context-dependent manner. Direct preclinical evidence for electronic nicotine delivery system–associated neurovascular impairment is provided, and a model is proposed in which non-nicotinic elements exert a proinflammatory effect that is functionally antagonized by the presence of nicotine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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