Bilayer permeability during phase transition as an Erlang flow of hydrophilic pores resulting from diffusion in the radius space
| Autor: | E.Yu. Smirnova, Andrej A. Anosov, O. Yu. Nemchenko, A. A. Sharakshane |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
030103 biophysics Phase transition Materials science Biophysics Analytical chemistry Biochemistry Quantitative Biology::Subcellular Processes 03 medical and health sciences symbols.namesake chemistry.chemical_compound Lipid bilayer phase behavior Lipid bilayer Physics::Biological Physics Quantitative Biology::Biomolecules Smoluchowski coagulation equation Stochastic process Bilayer Cell Biology Condensed Matter::Soft Condensed Matter Permeability (earth sciences) 030104 developmental biology chemistry Chemical physics symbols Ethylene glycol |
| Zdroj: | Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 11:8-16 |
| ISSN: | 1990-7494 1990-7478 |
| DOI: | 10.1134/s1990747816040139 |
| Popis: | The formation of hydrophilic pores in a lipid bilayer during phase transition is described using the Smoluchowski equation with an additional term of the hydrophobic pore source. This term is added to account for defects in lipid packing during phase transition. We assume that the temporal sequence of the pores is a stochastic process, a non-stationary second-order Erlang flow. Flow characteristics depend on the equation solution and determine the formation times of the hydrophilic pores. The calculated distribution of the durations of intervals between hydrophilic pores is in a good agreement with experimental data published before. In the context of this model we describe the influence of poly(ethylene glycol) on the pore formation frequency. |
| Databáze: | OpenAIRE |
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