Experimental Models for Autism Spectrum Disorder Follow-Up for the Validity
| Autor: | Abdulaziz S. Saeedan, Gaurav Kaithwas, Swetlana Gautam, Uma Devi, Jitendra K. Rawat, Vikas Kumar, Suchita Dubey, Rajnish Kumar Yadav, Mohd Nazam Ansari, Manjari Singh, Pushpraj S Gupta, Subhadeep Roy |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Social communication Cognitive Neuroscience medicine.disease behavioral disciplines and activities Social relation Developmental psychology 03 medical and health sciences Behavioral Neuroscience Psychiatry and Mental health 030104 developmental biology Developmental Neuroscience Chromosome (genetic algorithm) Autism spectrum disorder Molecular genetics mental disorders Genetic model medicine Autism Psychology Construct (philosophy) |
| Zdroj: | Review Journal of Autism and Developmental Disorders. 3:358-376 |
| ISSN: | 2195-7185 2195-7177 |
| DOI: | 10.1007/s40489-016-0088-7 |
| Popis: | Autism spectrum disorders (ASDs) are often considered to be genetic. They are characterized by unificational behavioral abnormalities which are classified in two basic domains: social relations and social communication, and restricted and repetitive pattern of behaviors and activity. Clinical research has evidenced that genetic and environmental factors play a major role in the development of ASD, and it is contemplated to be a multifactorial as well. Augmentation in the field of molecular genetics and neuroscience allows the pharmacologist to explore more features of ASDs using genetic, humanoid, and nonhumanoid models. Hence, the present review was undertaken to elucidate the major concepts associated with the models of ASD, such as gene or chromosome incrimination; face, predict, and construct validities; behavioral assays; and advantages and disadvantages of preclinical models along with constrains in developing genetic models for ASD. |
| Databáze: | OpenAIRE |
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