A new non-protein enediyne antibiotic N1999A2: Unique enediyne chromophore similar to neocarzinostatin and DNA cleavage feature

Autor:	Toshihiko Ando, Yukio Sugiura, Takayuki Kajiura, Toshiyuki Kameyama, Kiyoshi Miwa, Makoto Ishii
Rok vydání:	1998
Předmět:	Esperamicin Neocarzinostatin Dynemicin A biology Stereochemistry Organic Chemistry Chromophore biology.organism_classification Biochemistry Streptomyces chemistry.chemical_compound chemistry Drug Discovery Calicheamicin medicine Enediyne DNA medicine.drug
Zdroj:	Tetrahedron Letters. 39:6495-6498
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)01383-5
Popis:	The present NMR and X-ray structural studies demonstrated that the new antibiotic N1999A2 isolated from the broth filtrate of Streptomyces sp. AJ9493, possesses a novel 9-membered ring enediyne chromophore similar to neocarzinostatin, but is not chromoprotein. Of special interest is the fact that stable N1999A2 exists as enediyne chromophore alone as well as dynemicin A, esperamicin A 1 and calicheamicin γ 1 . The major difference between N1999A2 and neocarzinostatin chromophore is lack of the amino sugar in N1999A2. The antibiotic N1999A2 revealed more random DNA cutting profile than neocarzinostatin chromophore.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f9f4680cebb74b4bbd7c4257d75983e1 https://doi.org/10.1016/s0040-4039(98)01383-5 Zobrazit plný text záznamu Full Text from ScienceDirect