Semi-synthesis and proteasome inhibition of D -ring deoxy analogs of (–)-epigallocatechin gallate (EGCG), the active ingredient of green tea extract
| Autor: | Congde Huo, Wai Har Lam, Q. Ping Dou, Quizhi Cindy Cui, Tak Hang Chan, Di Chen, Guoqing Shi |
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| Rok vydání: | 2008 |
| Předmět: |
Active ingredient
Natural product Proteasome Inhibition Chemistry Stereochemistry Organic Chemistry food and beverages General Chemistry Gallate Green tea extract Epigallocatechin gallate Green tea complex mixtures Catalysis chemistry.chemical_compound Biochemistry Proteasome heterocyclic compounds sense organs |
| Zdroj: | Canadian Journal of Chemistry. 86:495-502 |
| ISSN: | 1480-3291 0008-4042 |
| DOI: | 10.1139/v07-141 |
| Popis: | A semi-synthetic route to the D-ring analogs of (–)-epigallocatechin gallate (EGCG) from the relatively abundant (–)-epigallocatechin (EGC), isolated from green tea leaves, is described. A natural product (13), found in Cistus salvifolius, its acetate (14) and analog (17) were synthesized by this method. Their inhibitory activities against proteasomes were investigated.Key words: green tea, (–)-epigallocatechin gallate (EGCG), (–)-epigallocatechin (EGC), proteasome inhibition. |
| Databáze: | OpenAIRE |
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