Effect of Sorafenib on Sex Hormone Levels in Male Swiss Albino Mice
| Autor: | B. Satheesha Nayak, AM Prasad, K. Laxminarayana Bairy, P Ashwini Aithal, Surekha D Shetty |
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| Rok vydání: | 2021 |
| Předmět: |
Sorafenib
Infertility endocrine system biology business.industry 030232 urology & nephrology Physiology 04 agricultural and veterinary sciences medicine.disease 040401 food science Male infertility 03 medical and health sciences Follicle-stimulating hormone 0404 agricultural biotechnology 0302 clinical medicine Sex hormone-binding globulin biology.protein medicine Pharmacology (medical) business Pharmacology Toxicology and Pharmaceutics (miscellaneous) Spermatogenesis Testosterone medicine.drug Hormone |
| Zdroj: | Research Journal of Pharmacy and Technology. :3883-3888 |
| ISSN: | 0974-360X 0974-3618 |
| DOI: | 10.52711/0974-360x.2021.00674 |
| Popis: | Background: Hormones play a vital role in initiating and maintenance of male reproductive or testicular function which includes the production of androgens and spermatozoa. Testosterone is essential for the initiation and maintenance of spermatogenesis. FSH is responsible for the stimulation of spermatogenesis. Semen analysis and hormone evaluation are essential parameters in the diagnosis of infertility in males. Objective: The aim of the present study is to evaluate the effect of sorafenib on FSH and intratesticular testosterone levels in male Swiss albino mice. Materials and Methods: The animals were segregated into control, positive control, and treatment groups (n=6). Treatment group received 25, 50 and 100 mg/kg body weight of sorafenib orally for seven consecutive days at intervals of 24 hours between two administrations. Positive control group received 100 mg/kg body weight of imatinib. The animals were sacrificed at the end of 1st, 2nd, 4th, 5th, 7th and 10th week after the last exposure to sorafenib. Results: The intratesticular testosterone level was significantly (P |
| Databáze: | OpenAIRE |
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