New bio-active, antimicrobial and adherent coatings of nanostructured carbon double-reinforced with silver and silicon by Matrix-Assisted Pulsed Laser Evaporation for medical applications
| Autor: | Dorota Bociaga, Mariana Carmen Chifiriuc, Coralia Bleotu, George E. Stan, Carmen Ristoscu, Veronica Lazar, Florin Miculescu, Maria Badiceanu, Ion N. Mihailescu, M.-A. Husanu, Emanuel Axente, Liviu Duta, Cristina Besleaga, Natalia Mihailescu |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Silicon medicine.medical_treatment General Physics and Astronomy chemistry.chemical_element 02 engineering and technology Thermal treatment engineering.material 010402 general chemistry 01 natural sciences medicine Irradiation Thin film Maple Excimer laser Surfaces and Interfaces General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Evaporation (deposition) 0104 chemical sciences Surfaces Coatings and Films Chemical engineering chemistry engineering 0210 nano-technology Carbon |
| Zdroj: | Applied Surface Science. 441:871-883 |
| ISSN: | 0169-4332 |
| DOI: | 10.1016/j.apsusc.2018.02.047 |
| Popis: | We report on Matrix-Assisted Pulsed Laser Evaporation (MAPLE) deposition of Carbon thin films, simple or reinforced with intended concentrations of Ag and Si. A KrF∗ (λ = 248 nm, τFWHM ≤ 25 ns, ν = 10 Hz) excimer laser was used for irradiation. The effect of a post-deposition thermal treatment in vacuum was studied. Besides detailed morphological, compositional, structural and pull-out adherence characterizations, the potential of the carbonaceous films for medical applications was investigated in vitro by anti-biofilm and cytocompatibility assays. The microscopic images evidenced no delaminations. Micro-Raman spectroscopy revealed a graphitization tendency depending on preparation conditions, thermal treatment and reinforcing agents’ presence. Adherence values improved considerably after thermal treatment. In vitro biological evaluation showed that the films containing ∼1.85 at.% Ag were non-cytotoxic for MG63 cells, while eliciting a limited antimicrobial activity. The increase of Ag content to 3.6 at.% results in a significant enhancement of antimicrobial activity, whilst maintaining the cytotoxic action and adherence characteristics at acceptable levels. We propose a new class of metamaterials based on C reinforced with Ag and Si obtained by MAPLE for medical applications, i.e. the prevention and treatment of various infections associated with biofilms developed on implants and other medical equipments. |
| Databáze: | OpenAIRE |
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