Two New Flavones from the Barks of Cassia alata and their Bioactivity
| Autor: | Yan-Ping Li, Yong-Qin Gen, Min Zhou, Jiang Ciqing, Kong Weisong, Ping Li, Guangyu-Yang, Jing Li, Xue-Mei Li, Gao-Xiong Rao, Liu Xin, Lin Ye, Qiu-Fen Hu |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Antioxidant Traditional medicine biology 010405 organic chemistry Chemistry medicine.medical_treatment Plant Science General Chemistry biology.organism_classification medicine.disease_cause 01 natural sciences Flavones General Biochemistry Genetics and Molecular Biology 0104 chemical sciences 010404 medicinal & biomolecular chemistry Cassia Staphylococcus aureus medicine Ic50 values Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Chemistry of Natural Compounds. 54:1052-1056 |
| ISSN: | 1573-8388 0009-3130 |
| Popis: | Two new flavones (1 and 2), together with two known flavones (3 and 4), were isolated from the barks of Cassia alata. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–4 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compound 1 showed good inhibition with IZD of 13.8 ± 1.0 mm. Compounds 2–4 also showed weak inhibition with IZD of 11.2 ± 0.8, 9.6 ± 0.6, and 7.8 ± 0.7 mm, respectively. Compounds 1 and 2 were also tested for their antioxidant activity, and show good antioxidant activity with an IC50 values of 4.8 and 4.5 μg/mL, respectively. |
| Databáze: | OpenAIRE |
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