Recognising the Sertoli-cell-only (SCO) syndrome: a case study
| Autor: | Ralph Brehm, Klaus Steger, R. Anniballo |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.diagnostic_test urogenital system Urology Cellular differentiation Connexin General Medicine Biology Sertoli cell Phenotype Cell biology Endocrinology medicine.anatomical_structure Antigen Internal medicine Biopsy medicine Germ cell Blood–testis barrier |
| Zdroj: | Andrologia. 43:78-83 |
| ISSN: | 0303-4569 |
| DOI: | 10.1111/j.1439-0272.2009.01030.x |
| Popis: | Total Sertoli-cell-only (SCO) syndrome is often confused with a focal SCO picture, in which testicular illness caused damage to seminiferous tubules and compromised the Sertoli cell range of maturation and functions, but from which still some spermatozoa can be retrieved for assisted reproductive techniques. Here, a possibly new SCO syndrome phenotype is reported exhibiting complete lack of germ cells despite normal architecture of the seminiferous tubules with presence of mature Sertoli cells and normal Leydig cells in the intertubular tissue. Sertoli cells are immunonegative for the prepubertal differentiation markers cytokeratin-18, anti-Muellerian hormone and M2A antigen, but reveal a positive signal for the gap junctional protein connexin 43 known to be expressed in Sertoli cells with an adult type of differentiation. The complete lack of germ cells in combination with fully differentiated adult-type Sertoli cells in this case is in contradiction with known SCO subtypes and with the current hypothesis of reciprocal regulation of Sertoli and germ cell differentiation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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