Antiproliferative and Antiviral Activity of Three Libraries of Adamantane Derivatives

Autor:	Nikola Basarić, Kata Mlinarić-Majerski, Jan Balzarini, Nikola Cindro, Margareta Sohora, Erik De Clercq
Rok vydání:	2014
Předmět:	biology Cell growth Adamantane Pharmaceutical Science RNA Pharmacology medicine.disease biology.organism_classification HeLa chemistry.chemical_compound Leukemia chemistry Biochemistry Drug Discovery Vero cell medicine Structure–activity relationship DNA
Zdroj:	Archiv der Pharmazie. 347:334-340
ISSN:	0365-6233
Popis:	Three libraries of adamantane derivatives were synthesized and evaluated for antiviral and antiproliferative activities against a broad variety of DNA and RNA viruses. Whereas none of the compounds exhibit antiviral activity at subtoxic concentrations, antiproliferative activity was found against murine leukemia cells (L1210), human T-lymphocyte cells (CEM), and cervix carcinoma cells (HeLa) for 4, 8, and 10.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f9befb8dbc4b9eb315d8ca9941010b6b https://doi.org/10.1002/ardp.201300345 Zobrazit plný text záznamu Plný text