Nanohybrid for Photodynamic Therapy and Fluorescence Imaging Tracking without Therapy
| Autor: | María González-Béjar, Julia Pérez-Prieto, Laura Francés-Soriano, José Manuel García-Verdugo, Dmitriy A. Pritmov, Andrey F. Mironov, Olga A. Fedorova, Marina A. Zakharko, M. A. Grin, Vicente Herranz-Pérez, Pavel A. Panchenko |
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| Rok vydání: | 2018 |
| Předmět: |
Fluorescence-lifetime imaging microscopy
Materials science General Chemical Engineering medicine.medical_treatment Photodynamic therapy 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Tracking (particle physics) Photochemistry 01 natural sciences Fluorescence Porphyrin Photon upconversion 0104 chemical sciences chemistry.chemical_compound chemistry Materials Chemistry medicine Photosensitizer 0210 nano-technology Absorption (electromagnetic radiation) |
| Zdroj: | Chemistry of Materials. 30:3677-3682 |
| ISSN: | 1520-5002 0897-4756 |
| DOI: | 10.1021/acs.chemmater.8b00276 |
| Popis: | Theranostic upconversion nanoparticles (UCNPs) are ideal candidates for personalized medicine. We present a smart, easy-to-prepare nanohybrid (NH) suitable for NIR-theragnosis and imaging tracking without triggering therapy simultaneously. The photophysical features of each component have been carefully selected in order to maximize the capabilities for theragnosis, in particular, the upconversion emission and the photosensitizer absorption. In addition, NH presents a fluorescent marker with one-photon absorption in the green and two-photon absorption cross-section at NIR wavelengths where the UCNP does not absorb, thus enabling innocuous tracking. Thus, the NH consists of NaYF4:Yb, Er, Tm (UCYbErTm) emitting in the UV, vis, and NIR; a broadband-absorbing natural porphyrin (PP) in the UV-to-NIR range but from 580 to 675 nm; and a 1,8-naphthalimide (NI) with two absorption bands (UV, VIS), and dual emission. In vitro assays demonstrate that UCYbErTm@PP/NI NH is noncytotoxic and extremely effective for NIR-... |
| Databáze: | OpenAIRE |
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