Estimation of skeletal calcium in humans by exhaled 37Ar measurement— Evaluation of the fast neutron dose requirement

Autor: Raymond Davis, Rodney E. Bigler, John Evans, John S. Laughlin
Rok vydání: 1976
Předmět:
Zdroj: International Journal of Nuclear Medicine and Biology. 3:105-110
ISSN: 0047-0740
DOI: 10.1016/0047-0740(76)90076-0
Popis: A low dose method for measuring the calcium content of a human subject in vivo is described. This method is pertinent to the diagnosis and monitoring during treatment of patients with metabolic bone disease. The sensitivity of fast neutron activation analysis by the 40 Ca( n , a) 37 Ar reaction has been investigated. A normal male human subject was irradiated using a 238 PuBe neutron source. Exhaled breath samples were taken over a three hour collection period following the start of a one-half hour irradiation. Whole-body radiation dose was limited to 0.6 mrad. Calculations based upon the results of this experiment demonstrate that a 1 % counting error assay can be carried out with as little as 10 mrad radiation exposure and a one day activity analysis.
Databáze: OpenAIRE