FTY720-Induced Conversion of Conventional Foxp3−CD4+ T Cells to Foxp3+ Regulatory T Cells in NOD Mice
| Autor: | Yi Lin, Bin Shan, Wenjing Wang, Da-Jin Li, Yun Sun, Jingfang Di, Weiping Li, Linlin Chen, Lingling Ren |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
biology business.industry Immunology Obstetrics and Gynecology FOXP3 hemic and immune systems chemical and pharmacologic phenomena Nod Molecular biology Proinflammatory cytokine Interleukin 21 Endocrinology Reproductive Medicine hemic and lymphatic diseases Internal medicine medicine biology.protein Immunology and Allergy IL-2 receptor Antibody Receptor business NOD mice |
| Zdroj: | American Journal of Reproductive Immunology. 66:349-362 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/j.1600-0897.2011.01010.x |
| Popis: | Citation Sun Y, Wang W, Shan B, Di J, Chen L, Ren L, Li W, Li D-J, Lin Y. FTY720-induced conversion of conventional Foxp3−CD4+ T cells to Foxp3+ regulatory T cells in NOD mice. Am J Reprod Immunol 2011; 66: 349–362 Problem FTY720 is known as an agonist of sphingosine-1-phosphate (S1P) receptor, but little is known about the possibility that FTY720 induces the conversion of conventional Foxp3−CD4+ T cells to Foxp3+ regulatory T cells in non-obese diabetic (NOD) mice. Method of study FTY720 treatment was performed using Foxp3−CD4+ T cells purified from NOD mice. Results FTY720 caused an increase in Foxp3+ Treg cells in lymphoid organs in NOD mice. FTY720 effectively induced Foxp3 expression in Foxp3−CD4+ T cells both in vitro and in vivo, an effect that was inhibited by a TGF-β-neutralizing antibody or the proinflammatory cytokine IL-6. T-cell-mediated embryo rejection in NOD mice was prevented upon FTY720 treatment. Conclusions The use of FTY720 along with Ag administration may represent a useful therapeutic strategy to selectively expand Ag-specific Foxp3+ Tregs to intervene autoimmune and infectious diseases. |
| Databáze: | OpenAIRE |
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