| Autor: |
Mary Ann S. Arndt, William D. Wheaton |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
American Journal of BioMedicine. 9:123-134 |
| ISSN: |
2333-5106 |
| DOI: |
10.18081/2333-5106/021-01/123-134 |
| Popis: |
The treatment of severe acute kidney injury with dialytic support for renal replacement therapy can be life sustaining and permit recovery from critical illness. The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. HMG proteins are present at high levels in various undifferentiated tissues during embryonic development and reduced in the corresponding adult tissues. We used used in study C57BL/6, HMG+/− and HMG−/− mice and found that HMG is expressed in the mouse embryonic kidney at the cortex area. HMG knockout led to enhanced Wnt/β-catenin signaling pathway. Analysis of siRNA-mediated loss-of-function experiments in embryonic kidney culture confirmed the role of HMG as a key regulator of cortex epithelium differentiation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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