Novel Chiral Fluorescent Labeling Reagent —4-Substituted 7H-benzo[de]benzoimidazo[2,1-a]isoquinolin-7-ones

Autor:	Kazumasa Funabiki, Ken-ichi Nakaya, Katsuyoshi Shibata, Masaki Matsui
Rok vydání:	2001
Předmět:	Detection limit Naproxen Diastereomer General Chemistry High-performance liquid chromatography Medicinal chemistry chemistry.chemical_compound Fluorescent labelling chemistry Reagent medicine Organic chemistry Acetonitrile medicine.drug
Zdroj:	Bulletin of the Chemical Society of Japan. 74:1463-1466
ISSN:	1348-0634 0009-2673
DOI:	10.1246/bcsj.74.1463
Popis:	(R)-4-(2-Hydroxy-1-phenylethylamino)-7H-benzo[de]benzoimidazo[2,1-a]isoquinolin-7-one was used as a fluorescent labeling reagent for Naproxen. The excitation and emission maxima of this reagent were observed at λ 453 and 508 nm in acetonitrile, respectively. This reagent reacted with racemic Naproxen in the presence of dicyclohexylcarbodiimide to afford the corresponding diastereomers, which were nicely separated in HPLC. The detection limit (S/N > 3) of Naproxen was ca. 5 fmol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f9b198f5963dd37b76b736f3e4fb6442 https://doi.org/10.1246/bcsj.74.1463 Zobrazit plný text záznamu