Vitamin D is Related to Markers of Vulnerable Plaque in Acute Myocardial Infarction
| Autor: | Federico Blanco, Bibiana Fabre, Alejandro García Escudero, Laura Schreier, Juan Gagliardi, Gerardo Gigena, Micaela Lombardo, Gabriela Berg, Magalí Barchuk, Nahuel Fernandez Machulsky, Diego Gonzalez |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
medicine.medical_specialty Acute coronary syndrome business.industry Leptin 030204 cardiovascular system & hematology medicine.disease medicine.disease_cause Vulnerable plaque Bone remodeling Coronary artery disease 03 medical and health sciences 0302 clinical medicine Fat-Soluble Vitamin Endocrinology 030220 oncology & carcinogenesis Internal medicine medicine Vitamin D and neurology Myocardial infarction Cardiology and Cardiovascular Medicine business |
| Zdroj: | Current Vascular Pharmacology. 16:355-360 |
| ISSN: | 1570-1611 |
| DOI: | 10.2174/1570161115666170609102506 |
| Popis: | Background: Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque. Objective: To investigate whether the association between vitamin D and leptin is related to markers of vulnerable plaque, such as MMPs in patients with acute myocardial infarction. Methods: We studied 66 male patients with acute myocardial infarction, undergoing primary angioplasty. Blood samples were obtained at admission and 24hs after the surgery. Leptin and vitamin D concentrations in serum and MMP-2 and -9 activities in plasma were determined. Results: MMP-2 activity was increased in Vitamin D deficient/insufficient patients at admission (p=0.04) and 24 hs later (p=0.05). In a linear regression model, vitamin D explained 24% of the variance of MMP-2 activity (F=2.839 p=0.04). At admission, vitamin D correlated with serum leptin (r=-0.302 p=0.033), and explained 39.5% of its variation (F=4.432 p=0.003). Conclusions: In the studied population, vitamin D was inversely related to MMP-2 and leptin which are involved in coronary artery disease and acute myocardial infarction. The decrease in this hormone levels would be associated with a worse metabolic profile in acute coronary syndrome patients. |
| Databáze: | OpenAIRE |
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