Does Percutaneous Transluminal Coronary Angioplasty Activate Neutrophils ? Preliminary Clinical Result
| Autor: | Jacques Hakim, Jean-Michel Juliard, René Gourgon, P. Gabriel Steg, Marie-Anne Pocidalo, Trung Pham Huu, Dominique Himbert, Catherine Pasquier, Sylvie Chollet-Martin |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
biology business.industry medicine.medical_treatment Zymosan medicine.disease Angina chemistry.chemical_compound Restenosis chemistry Catheterization procedure Myeloperoxidase Angioplasty Internal medicine biology.protein medicine Cardiology Myocardial infarction business Coronary sinus |
| Popis: | It has been suggested that activation of neutrophils and the complement system plays a role in post-ischemic myocardial dysfunction and restenosis after coronary angioplasty. Furthermore, recent experimental evidence suggests activation of the neutrophils in angina pectoris and acute myocardial infarction. Percutaneous transluminal coronary angioplasty (PICA) represents both a controlled injury to the coronary arterial wall, and a model of transient ischemia. Both of these processes are liable to activate neutrophils.The aim of this study was to investigate ex vivo the morphological and functional characteristics of coronary sinus neutrophils, before and immediately after PTCA. Neutrophil activation was assessed by 1.measurement of plasma lactoferrin (LF) and plasma myeloperoxidase, to study release of specific and azurophilic granules respectively, 2.whole blood chemiluminescence stimulated in vitro by phorbol-myristate acetate and opsonized zymosan, 3.plasma fluorescent thiobarbituric acid-reactive substances (TBA-RS). These measurements were performed in blood drawn from the coronary sinus, before and immediately after PICA (7 Pts). To ensure that changes observed were related to PTCA but not to the catheterization procedure, controls undergoing coronary angiography without PICA were also studied. (4 Pts).After PTCA, LF increased 2 fold (p |
| Databáze: | OpenAIRE |
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