Dimethylformamide Dimethyl Acetal (DMFDMA) in Heterocyclic Synthesis: Synthesis of Polysubstituted Pyridines, Pyrimidines, Pyridazine and Their Fused Derivatives

Autor:	E. A. Eshak, Fathi A. Abu-Shanab, Ahmed Sayed, Sayed A. S. Mousa, Ahmed Al-Harrasi
Rok vydání:	2011
Předmět:	Amidine Pyridazine chemistry.chemical_compound Cyanoacetamide chemistry Pyrimidine Dimer Pyridine Dimethylformamide Medicinal chemistry Malononitrile
Zdroj:	International Journal of Organic Chemistry. :207-214
ISSN:	2161-4695 2161-4687
Popis:	Reaction of N,N’-dimethylformamide dimethyl acetal (DMFDMA) with malononitrile dimer 8 (1:1) mole afforded 9 while, this reaction when carried out in (2:1) mole to give amidine 11 which can be used for the preparation of pyrimidine 13, amidine 14 and pyridine 19 when reacted with 4-nitroaniline, 4-methylaniline and alkoxide respectively. Malononitrile dimer reacted with diazonium chloride to give pyridazine 21, which can be reacted with DMFDMA, AcOH/HCl and cyanoacetamide to give pyridazine 22, 23 and pyrido[4,3-c] pyridazine 24 respectively. The latter reacted with DMFDMA to afford tricyclic compound 25.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f9a2ade8d9db5b5ff014c4be25a5c461 https://doi.org/10.4236/ijoc.2011.14030 Zobrazit plný text záznamu