Gas and Liquid Chromatographic Investigations into Alkylnitrile Compounds Containing Amine Impurities

Autor:	C. F. Simpson, S. D. McCrossen
Rok vydání:	1996
Předmět:	Chromatography Nitrile Chemistry Clinical Biochemistry Pharmaceutical Science Chemical modification Mass spectrometry Biochemistry High-performance liquid chromatography Analytical Chemistry chemistry.chemical_compound Impurity Amine gas treating Gas chromatography Aliphatic compound
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 19:2785-2797
ISSN:	1520-572X 1082-6076
DOI:	10.1080/10826079608015110
Popis:	The purity of alkylnitrile compounds has been investigated using gas chromatography (GC), gas chromatography-mass spectrometry (GC-MS) and high performance liquid chromatography (HPLC). The investigation was carried out to supplement earlier reported work using the alkylnitrile compounds, hexanenitrile and valeronitrile, as mobile phase additives in HPLC. GC impurity profiling and GC-MS experiments showed the presence of low level nitrogenous impurities in the alkylnitrile compounds. Analytical interrogation and chemical isolation were employed to identify the impurities as alkylamines. Tri-n-butylamine (TBA) and di-n-pentylamine (DPA) impurities were found in batches of hexanenitrile and valeronitrile respectively and it was found that it was the amine impurities, at very low levels, which caused the observed chromatographic improvements for basic solutes when using the alkylnitrile compounds as mobile phase additives in reversed-phase HPLC. The amines themselves were subsequently used at extrem...
Databáze:	OpenAIRE
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