| Autor: |
Arthur White, M. Garten, M. L. V. French, R. B. Kohler, Lawrence J. Wheat, W. Schlech, Z. Brahmi, J. Ho, S. E. Zimmerman, M. Kleiman |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
American Review of Respiratory Disease. 128:65-70 |
| ISSN: |
0003-0805 |
| DOI: |
10.1164/arrd.1983.128.1.65 |
| Popis: |
Radioimmunoassays for IgM and IgG histoplasmal antibodies were developed and proved to be specific for their respective immunoglobulin classes, sensitive, and reproducible. Elevated IgM antibodies were detected in 59.8% of patients with histoplasmosis and 7.9% of control subjects. Elevated IgG antibodies occurred in 80.4% of patients with histoplasmosis but in only 12.9% of control subjects. Radioimmunoassay was nearly twice as sensitive as complement fixation for identifying patients with mild, presumably asymptomatic, infection. Of 13 patients with serologic follow-up at least 1 yr later, elevated IgM antibodies cleared, whereas IgG antibodies persisted in 7. In an epidemiologic investigation of a recurrent histoplasmosis outbreak, only the radioimmunoassay was able to prove the hypothesis that construction for a swimming complex was the source of exposure. These assays promise to be useful for clinical and epidemiologic investigations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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