Ultrastructural and Immunohistochemical Evidence of Measles Virus in Active Otosclerosis
| Autor: | Michael J. McKenna, Barbara G. Mills |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pathology
medicine.medical_specialty biology Immunoperoxidase business.industry viruses General Medicine medicine.disease biology.organism_classification Virology Measles Subacute sclerosing panencephalitis Measles virus Otorhinolaryngology Antigen medicine Otosclerosis Immunohistochemistry business Stapes |
| Zdroj: | Acta Oto-Laryngologica. 109:130-140 |
| ISSN: | 1651-2251 0001-6489 |
| Popis: | Because of the similarity between otosclerosis and Paget's disease of bone, and the mounting evidence of a viral cause in Paget's disease, we have investigated a possible viral cause for otosclerosis. Transmission electron microscopy of stapes footplate fragments with active otosclerosis has revealed structures morphologically identical with measles virus nucleocapsid in osteoblasts and preosteoblasts. lmmunofluorescence and immunoperoxidase studies have confirmed the presence of measles nucleocapsid antigen in active lesions. Application of sera from patients with subacute sclerosing panencephalitis, a defective measles virus infection of the central nervous system, resulted in positive immunoreaction in areas of active otosclerosis. |
| Databáze: | OpenAIRE |
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