Effects of Sophorae Radix on skin condition in mice with contact dermatitis induced by Dinitrofluorobenzene
| Autor: | Won-Ju Cheon, Jeonghyun Ryu, Won G. An, Yonghae Son, Suzy Jo, Hyungwoo Kim, Su In Cho |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Pathology Sophora flavescens integumentary system biology business.industry Gallbladder Spleen Sophorae Radix biology.organism_classification medicine.disease Skin thickness Dermatology medicine.anatomical_structure Dinitrofluorobenzene medicine business Contact dermatitis Spongiosis |
| Zdroj: | The Korea Journal of Herbology. 28:25-29 |
| ISSN: | 1229-1765 |
| DOI: | 10.6116/kjh.2013.28.6.25 |
| Popis: | Objectives : The dried root of Sophora flavescens Aiton have been used to treat patient with skin diseases such as eczema in Eastern countries. S. flavescens can clear away heat and dry dampness and purge sthenic-fire from the liver and gallbladder. Recently, anti-allergic effect of S. flavescens has been reported. However, the effect on skin condition of contact dermatitis still remains un known. Thus, the purpose of this study is to evaluate the efficacy of S. flavescens on contact dermatitis. Methods : In order to investigate the effects of S. flavescens (methanol extract of S. flavescens, MESR) on skin condition, the contact dermatitis was induced in mice skin by using 1-fluoro-2,4-dinitrofluorobenzene (DNFB). As the effective endpoints, skin thickness, skin weight, histopathological change were checked. In addition, effects on skin lesion, body weight and spleen/body weight ratio were also investigated. Results : Topical application of MESR (500 ㎍/day) lowered skin thickness (P < 0.05) and skin weight (P < 0.05), respectively. MESR-treated group showed diminished spongiosis and immune cell infiltration in skin tissues compared to those of non-treated control group. The inhibition of skin lesions was also observed in MESR-treated group. In addition, MESR did not affect body weigh t gain and spleen / body weight ratio in contrast with those in dexamethasone-treated group. Conclusion : These data suggest that Sophorae Radix could improve skin lesion of contact dermatitis. This indicates the possibility for Sophorae Radix to be used to patients with skin diseases such as contact dermatitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|