Immediate-Early Gene Expression in Neural Circuits Related to Object Recognition Memory
| Autor: | Regina H. Silva, Flávio Freitas Barbosa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Arc (protein) Cognitive neuroscience of visual object recognition Biology Object (computer science) Expression (mathematics) 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Biological neural network Premovement neuronal activity Neuroscience Immediate early gene 030217 neurology & neurosurgery Recognition memory |
| Popis: | The novel object recognition test (NORT) for rodents has been widely used to investigate the neural mechanisms that underlie spatial (e.g., what) and nonspatial memory (e.g., where) as well as temporal order memory (e.g., when). The processing and retrieval of what, where and when a specific event occurred in NORT led to expand this test to assess episodic-like memory (ELM) in rodents. Different variations of NORT exist and have been used to assess each component of the memory of an object separately (e.g., what or where) or in different combinations (what–where, what–when or what–where–when). Immediate-early genes (IEGs) are markers of neuronal activity that have been used to identify the brain areas that are involved in these various forms of recognition memory. In this chapter, we review studies on IEG (c-fos, zif-268, arc) expression in mouse and rat brains exposed to different variants of NORT and discuss the involvement of neural circuits related to spatial, nonspatial and ELM. |
| Databáze: | OpenAIRE |
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