| Autor: |
F.C. Hillen, J. van Dijk, J. Hartog |
| Rok vydání: |
1978 |
| Předmět: |
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| Zdroj: |
Progress in Medicinal Chemistry ISBN: 9780720406559 |
| DOI: |
10.1016/s0079-6468(08)70258-3 |
| Popis: |
Publisher Summary This chapter discusses recent developments in “non-tricyclic antidepressants” and the test methods on which the conclusion of “probably therapeutically active” is based have been evaluated. The chapter discusses the activities of the various new structures, classified by structural resemblance. Some general structure-activity relations (SAR) are also discussed in the chapter. In general, the therapeutic properties of tricyclic antidepressant drugs are attributed to their inhibition of a transmitter uptake by monoaminergic neurons in the central nervous system. This hypothesis is based mainly on the pharmacological properties of these tricyclics in animal experiments viz. the antagonism of monoamine depleting agents, the potentiation of directly or indirectly acting amine agonists, and the decrease in amine uptake processes by appropriate cells or cell fragments. In the non-tricyclic antidepressant, structures there are promising drugs in which the side effects of the tricyclics are absent. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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